Human epididymis protein 4 (HE4)

HE4 Antibody

Name	Anti- Human epididymis protein 4 (HE4) antibody
Platforms	Chemiluminescence immunoassay (CLIA)
Catalog #	R206k7	R207c8	R208a2	R209e9
Usage	Detection	Capture	Detection/Capture	Detection/Capture
Description	Mouse monoclonal antibody, cultured in vitro
Buffer	1 x PBS
Purity	Purity>95%, purified by Protein A/G chromatography
Storage	Aliquot and store at -20°C or lower. Avoid freeze / thaw cycles.

HE4 Antigen

Name	Human epididymis protein 4 (HE4) antigen
Description	Recombinant, C-terminal His-tagged, in vitro expressed from mammalian cells
Applications	Calibrator and quality control product
Catalog #	C1548
Purity	>90%, analyzed by R250-stained SDS-PAGE
Buffer	1 x PBS，pH 7.4
Storage	Aliquot and store at -80°C. Avoid freeze / thaw cycles.
SDS-PAGE	Predicted MW around 11 kDa

Product Information

Updating

Introduction to Human epididymis protein 4 (HE4)

Human epididymis protein 4 (HE4), also known as whey acidic protein-four-disulfide core domain 2 (WFDC2), is a secreted glycoprotein and a member of the whey acidic protein (WAP) family with a molecular weight of 22-26kDa. Mature HE4 consists of 94 amino acids and contains two highly conserved WAP domains.

The HE4 coding gene WFDC2 is expressed in various epithelial cells such as the fallopian tube epithelium and endometrial glands in women, the distal end of the epididymis and the vas deferens in men. The expression level of HE4 is low in normal tissues, but it is usually overexpressed in tumor tissues of ovarian cancer and endometrial cancer. Gene overexpression experiments showed that HE4 overexpression promotes anchorage-independent growth of endometrial cancer cells, inhances the ability of cancer cells to migrate and invade matrix gel or muscle layer. HE4 plays an important role in the proliferation and malignant transformation of cancer cells, and it has important reference significance for the diagnosis prognosis judgment, as well as monitoring of ovarian cancer, endometrial cancer and other tumors.

Reference

[1] Jinping Li, Haibin Chen, Andrea Mariani, et al. HE4 (WFDC2) promotes tumor growth in endometrial cancer cell lines[J]. Int. J. Mol. Sci, 2013, 14: 6026-6043.